Conventional genotoxic anti-cancer drugs target the proliferative advantage of tumor cells over normal cells.This kind of approach lacks the selectivity of treatment to cancer cells, because most of the targeted pathways are essential for the survival of normal cells.As a result, traditional cancer treatments are often limited by undesirable damage
BACKGROUND: Since the 1950s, mental health care in Japan has been hospital-centered.A set of legislative initiatives were undertaken in 1995, emphasizing the importance of community-based mental health care.However, despite these attempts to develop a community-based mental health care system, the rate of Privacy Booths inpatient-based treatment ha
Abstract Background Paratransit is a system that operates along a more P-5-P or less defined route and then stops to take passengers on demand.They offer on-demand door-to-door service from any origin to any destination in a service area, and are operated by public transit agencies, community groups or not-for-profit organizations, and for-profit p
Skin diseases are mainly divided into infectious diseases, non-infectious inflammatory diseases, cancers, and wounds.The pathogenesis might include microbial infections, autoimmune responses, aberrant cellular proliferation or differentiation, and the overproduction of inflammatory factors.The traditional therapies for skin diseases, such as oral o
Objectives Autoimmune rheumatic diseases (ARDs) affect women of childbearing age and have been associated with adverse birth outcomes.The impact of diseases like ankylosing spondylitis and psoriatic arthritis (PsA) on birth MAG-K-TAURINE outcomes remains less studied to date.Our objective was to evaluate the impact of ARDs on preterm birth (PTB), c